A SUBSET OF CB002 XANTHINE ANALOGS BYPASS P53-SIGNALING TO RESTORE A P53 TRANSCRIPTOME AND TARGET AN S-PHASE CELL CYCLE CHECKPOINT IN TUMORS WITH MUTATED-P53

Mutations in TP53 occur commonly in the majority of human tumors and confer aggressive tumor phenotypes, including metastasis and Bead Roller therapy resistance.CB002 and structural-analogs restore p53 signaling in tumors with mutant-p53 but we find that unlike other xanthines such as caffeine, pentoxifylline, and theophylline, they do not deregula

Very few experimental studies of full pinion engagement planetary gear trains have been published; therefore, their behavior under load is little known.In this paper, the results pyjamas from the experimental studies of the above-mentioned gear trains are presented, whereby the bending stresses in the planet pins are displayed both in time and freq

We provide here a comparative genome analysis of ten strains within the Pseudomonas fluorescens group including seven new genomic sequences.These strains exhibit a diverse spectrum of traits involved in biological control and other multitrophic interactions with plants, microbes, and insects.Multilocus sequence analysis placed the strains in three

In case pressurized water or vapor leaks from a failed heat transfer tube in a steam generator of a sodium-cooled fast reactor, a high-velocity, high-temperature, and corrosive jet with sodium-water chemical reaction may cause tube failure propagation.In this study, a numerical analysis method Scale to predict the occurrence of tube failure propaga